Dr. Qin Liu

Associate professor

Department of Biology
University
of Akron
Akron,OH
44325-3908

330-972-7558
330-972-8445
qliu@uakron.edu

 

My primary research interest is to understand the molecular mechanisms underlying fundamental cellular processes in vertebrate neural development. I have chosen to study zebrafish, which in recent years has become one of the most important animal models for studies of vertebrate development. My specific research focus is on the expression and function of cadherin cell adhesion molecules in the development of zebrafish nervous system. In collaboration with Dr. James Marrs (Indiana University), Dr. Kate Barald (University of Michigan), Dr. Richard Londraville, University of Akron) and Dr. Brian Bagatto, we have studied cadherin expression and function in the visual, auditory, cardiovascular, and cranial ganglia and lateral line systems of developing zebrafish.

Education   Research Interests   Teaching   Research Grants   Graduate Students   Publications

 

  Education

 

  Research Interests

  • Anatomy and development of vertebrate central nervous system (CNS)
  • Molecular mechanisms underlying development of vertebrate sensory systems
  • Expression and function of cell adhesion molecule cadherins in the development of vertebrate nervous tissue

 

  Teaching

  • Neurobiology (Fall)
  • Vertebrate embryology (Spring)

 

  Research Grants

Current

1. Title: Characterization of leptin's effects in early developing and adult zebrafish. Funding agency: National Institute of Diabetes and Digestive and Kidney Diseases. Grant period: July 1, 2008 to June 30, 2011; $220,500. PI: Richard Londraville, University of Akron; Co-PIs: Qin Liu and Brian Bagatto.

2. Title: Cadherin-6 and -10 function in retinal ganglion and amacrine cell development. Funding agency: National Eye Institute. Grant period: July 1, 2007 to June 30, 2010; $220,500. PI: Qin Liu. Co-PI: Richard Londraville. Matching fund from the Ohio Board of Reagents, $15,000.

 

Past

1. Title: Role of cadherins in the developing zebrafish cardiovascular system. Funding agency: National Heart, Blood and Lung Institute. Grant period: July 1, 2005 to June 30, 2008; $220,500. PI: Brian Bagatto, University of Akron; Co-PI: Qin Liu.

2. Title: Cadherins in the developing zebrafish inner ear. Funding agency: National Institute on Deafness and Other Communication Disorders. Grant period: July 1, 2004 to June 30, 2007 $837,080. PI: James A. Marrs, Indiana University; Co-PIs: Kate F. Barald, University of Michigan; Qin Liu, University of Akron (25% effort).

3. Title: Cadherins function in the developing retinal ganglion cells. Funding agency: National Eye Institute. Grant period: April, 2004 to March, 2007, $147,000. PI: Qin Liu.

4. Title: Cell adhesion function in the visual system. Funding agency: National Eye Institute. Grant period: April 30, 2002 to March 30, 2005, $1,117,500. PI: Dr. James Marrs (Indiana University). Qin Liu, Co-investigator (10% effort). Matching fund from the Ohio Board of Reagents, July 1, 2002 to April 30, 2003, $13,364.

5. Title: R- and N-cadherin in the development of zebrafish retinal ganglion cells. Funding agency: NIH. Grant period: April 1, 2001 to March 30, 2004, $146,000. PI. Qin Liu. Matching fund from the Ohio Board of Regents, April 1, 2001 to March 30, 2002, $20,000.

 

 

 

  Graduate Students

  • Thomas Mbimba (Master degree, 2007), is a research assistant at WIL RESEARCH LAB, Ashland, OH.
  • Amy Wilson (Master degree, 2007) is a research technician at the University of Kentucky Medical Center.
  • Bing Zeng (2003-2006) graduated in 2006. A research associate at MD Anderson Cancer Center, University of Texas, Houston TX.
  • Mitsuyo Kohama (2003-2004) is a medical student at the Northeast Ohio Universities College of Medicine.
  • Elaheh Azodi (Master degree, 2004) is a Ph.D. student in the Department of Cell and Molecular Biology at the Cleveland State University.
  • Amber Kerstetter (Master degree, 2004) is a Ph.D. student in the Neuroscience Program at the Case Western Reserve University Medical Center.
  • Russ Ensign (Master degree, 2003) is a medical student at the Lake Erie College of Osteopathic Medicine.
  • Shannon Kortradi (Master degree, 2003) is a Ph.D. student in the Neuroscience Program at the Case Western Reserve University Medical Center.
  • Zackary Novince (Master degree, 2002) is a research associate at the Cleveland Clinics.

 

  Publications

  • Liu, Q., J.A. Marrs, R.L. Londraville, A.L. Wilson. 2008. Cadherin-7 function in zebrafish development. Cell and Tissue Res., in press..
  • Liu, Q., R.L. Londraville, J.A. Marrs, A.L. Wilson, T. Mbimba, T. Murakami, F. Kubota, W. Zheng, and D.G. Fatkins, 2008. Cadherin-6 function in zebrafish retinal development. Dev. Neurobiol., 68:1107-1122.
  • Aquilina-Beck, A., K. Ilagan, Q. Liu, and J.O. Liang, 2007. Nodal signaling is required for closure of the anterior neural tube in zebrafish. BMC Dev. Biol. 7:126.
  • Wilson, A., Y. Shen, S.G. Babb-Clendenon, J. Rostedt, B. Liu, K.F. Barald, J.A. Marrs, and Q. Liu, 2007. Cadherin4 plays a role in the development of zebrafish cranial ganglia and lateral line system. Dev. Dynamics, 236:893-902.
  • Liu, Q., R.A. Frey, S.G. Babb-Clendenon, B. Liu, J. Francl, A.L. Wilson, J.A. Marrs, and D.L. Stenkamp, 2007. Differential expression of photoreceptor-specific genes in the retina of a zebrafish cadherin-2 mutant glass onion and zebrafish cadherin-4 morphants. Exp. Eye Res., 84:163-175.
  • Liu, B., R.J. Duff, R.L. Londraville, J.A. Marrs, and Q. Liu. 2007. Cloning and expression analysis of cadherin7 in the central nervous system of the embryonic zebrafish. Gene Expr. Patt., 7:15-22.
  • Babb-Clendenon, S.G., Y. Shen, Q. Liu, K.E. Turner, M.S. Mills, K.F. Barald, and J.A. Marrs, 2006. Cadherin-2 controls morphogenesis of the zebrafish inner ear. J. Cell Sci., 119:5169-5177.
  • Liu, Q. R.J. Duff, B. Liu, A.L. Wilson, S.G. Babb-Clendenon, J. Francl and J.A. Marrs. 2006. Expression of cadherin-10, a type II classic cadherin gene, in the nervous system of the embryonic zebrafish. Gene Expr. Patt., 6:703-710.
  • Bagatto, B., B. Liu, J. Francl, and Q. Liu. 2006. Cadherin-2 plays an essential role in zebrafish cardiovascular development. BMC Developmental Biology, 6:23.
  • Liu, Q. B. Liu, A.L. Wilson, and J. Rostedt. 2006. cadherin-6 message expression in the nervous system of developing zebrafish. Dev. Dynamics, 235:272-278.
  • Babb, S.G., S.M. Kotradi, B. Shah, C. Chiappini-williamson, L.N. Bell, G. Schmeiser, E. Chen, Q. Liu, and J.A. Marrs. 2005. Zebrafish R-cadherin (Cdh4) controls visual system development and differentiation. Dev. Dynamics, 233:930-945.
  • Liu, Q., J.A. Marrs, E. Azodi, A.E. Kerstetter, S.G. Babb, and L. Hashimi. 2004. Differential expression of cadherins in the developing and adult zebrafish olfactory system. J. Comp. Neurol., 478:269-281.
  • Liu, Q., E. Azodi, A.E. Kerstetter, and A.L. Wilson. 2004. Cadherin-2 and cadherin-4 in developing, adult and regenerating zebrafish cerebellum. Dev. Brain Res., 150:63-71.
  • Kerstetter, A., E. Azodi, J.A. Marrs, and Q. Liu. 2004. Cadherin-2 function in the cranial ganglia and lateral line system of developing zebrafish. Dev. Dynamics, 230:137-143.
  • Liu, Q., and R.L. Londraville. 2003. Using adult zebrafish visual system to study cadherin-2 expression during central nervous system regeneration. Methods in Cell Science, 25:71-78.
  • Liu, Q., A. Kerstetter, E. Azodi, and J.A. Marrs. 2003. Cadherin-1, -2 and –11 expression and cadherin-2 function in the pectoral limb bud and fins of developing zebrafish. Dev. Dynamics, 228:734-739.
  • Liu, Q., R.D. Ensign, and E. Azodi. 2003. Cadherin-1, -2, and -4 expression in the cranial ganglia and lateral line system of developing zebrafish. Gene Expression Patterns, 3:653-658.
  • Novince, Z.M., E. Azodi, J.A. Marrs, P.A. Raymond, and Liu, Q. 2003. Cadherin expression in the inner ear of developing zebrafish. Gene Expression Patterns, 3:337-339.
  • Liu, Q., R.L. Londraville, E. Azodi, S. G. Babb, C. Chiappini-williamson, J.A. Marrs, and P.A. Raymond. 2002. Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafish. Exp. Neurol., 177:396-406.
  • Liu, Q., S.G. Babb, Z.M. Novince, J.A. Marrs, and P.A. Raymond. 2001. Differential expression of cadherin-2 and cadherin-4 in the developing zebrafish visual system. Vis. Neurosci., 18:923-933.
  • Liu , Q., J.A. Marrs, J.C. Chuang and P.A. Raymond. 2001. R-cadherin expression in the zebrafish central nervous system and regulation by ventral midline signaling. Dev. Brain Res., 131:17-29.
  • Babb, S.G., J. Barnett, A.L. Doedens, N. Cobb, Q. Liu, B.C. Sorkin, P.C. Yelick, P.A. Raymond, W.J. Gallin, and J.A. Marrs. 2001. Zebrafish E-cadherin: phylogenic analysis, expression during early embryogenesis and regulation during midbrain hindbrain boundary formation. Dev. Dynamics, 221:231-237.
  • Liu , Q., J.A. Marrs, and P.A. Raymond. 1999b. Spatial correspondence between R-cadherin expression domains and retinal ganglion cell axons in developing zebrafish. J. Comp. Neurol. 410:290-302.
  • Liu , Q., K.L. Sanborn, N. Cobb, P.A. Raymond, and J.A. Marrs. 1999a. R-cadherin expression in the developing and adult zebrafish visual system. J. Comp. Neurol. 410:303-319.
  • Yang, L., Q. Liu and G.D. Pollak. 1996. Afferent connections to the dorsal nucleus of the lateral lemniscus of the mustache bat: evidence for two functional subdivisions. J. Comp. Neurol. 373:575-592.
  • Liu, Q. and E.A. Debski. 1996. Optic nerve dependent changes in adult frog tectal phenotypes. J. Neurobiology. 29:517-534.
  • Debski, E.A., Q. Liu and A. Chapman. 1995. Non-uniform distribution of cellular phenotypes in the optic tectum of the leopard frog. J. Comp. Neurol. 360:671-684.
  • Liu, Q. and E.A. Debski. 1995. Origins of serotonin-like immunoreactivity in the optic tectum of Rana pipiens. J. Comp. Neurol. 352:280-296.
  • Liu, Q. and E.A. Debski. 1993. Serotonin-like immunoreactivity in the adult and developing retina of the leopard frog Rana pipiens. J. Comp. Neurol. 338:391-404.
  • Liu, Q. and L.S. Demski. 1993. Clasper control in the round stingrays, Urolophus Halleri: lower sensorimotor pathways. Environmental Biology of Fishes. 38:219-230.

 

 

 

UA HomePage       Department of Biology