Curriculum Proposal System
Course Details

Prerequisites (list each individually, one course per line, with course number and title)
3100:437/537 Immunology prerequisites to be checked at time of registration? yes
Corequisites (list each individually, one course per line, with course number and title)
corequisites to be checked at time of registration? no
Bulletin description
Prequisite: 437/537. Immunology is studied from a historical and current perspective. Topics include T cells, B cells, antigen presentation, HIV, and transplantation.
Web Components
Textbook selection
Cellular and Molecular Immunology, 3rd ed. A. K. Abbas; A.H. Lichtman; J. S. Dober. Saunders Pub., 1997.
Rationale
This has been offered as a Special Topics course and is now presented as a formal course. Immunology 437/537 is a survey course in Immunology. There is not time in this course to read the original literature or to analyze data from specific experiments. The proposed course allows students time to read the original literature and delve in specific areas in greater detail. Students will also be expected to read, interpret and analyze data.
Syllabus
Advanced Immunology 439/539 Instructor J. Holda Office 385 ASEC office hr Mon. Wen. 3-4:00 Ext. 5116 The purpose of this class is for the student to become familiar with the study of Immunology at an advanced level. We will also discuss some of the latest advances in Immunology. The course is designed so that students will be required to read original literature in the field of Immunology. Students will also be required to use the library and its resources. Text. No text is required. It is important that students have a current Immunology text for reference. I recommend CELLULAR AND MOLECULAR IMMUNOLOGY, 3rd ed. by Abul K. Abbas, Andrew H. Lichtman, and Jordan S. Pober. Saunder Pub. 1997. Reading material will be available. It would be nice to have a 3 ring binder to place them in. Graduate students will be expected to not only present 2 papers but also give background information concerning the topic and explain the significance of this article. Undergraduate Grading: 40% of the grade will be based on a paper dealing with a topic in Immunology (see below). 40% will be based on one test (40 pts). 20% will be based on student's presentation of 1 paper and also class participation. Graduate Grading: 40% of the grade will be based on a paper dealing with a topic in Immunology (see below). 40% will be based on one test (40 pts). 20% will be based on student's presentations of 2 papers and also class presentation. Lecture: The first portion of the semester will be lecture dealing with selected topics in Immunology. Hopefully the lectures will bring everyone to a level of understanding in Immunology so that they can read the current literature with some understanding. A test will be given at the conclusion of the lecture portion of the course. Presentations: Students will be required to present at least 1 assigned paper in class. Depending on the number of students and how long I lecture there could be additional student presentations. All students are to read the paper that is to be presented in class. Test: The exam will be a take-home exam. I will give you a paper from the literature with vital information deleted, like the data interpretation. It will be you assignment to interpret the data in the paper and come up with conclusions. Paper: A paper of approximately 8-10 pages in length will be due the last week of class. The paper should contain reference to a least 8 original research papers. Reviews, books, etc. can be used also but these are not considered original research articles. References should be cited as in the Journal of Immunology. The paper is worth 40 points; 35 points for the final paper and 5 points for a 1 page outline of your topic by Mid term. The outline should include at least four potential references.
Bibliography
Arnon, R. Synthetic Vaccines. From Immune Intervention, Academic press. 1984. Edt. I.M. Roitt. Weigert, M. et. al.1974. Immunochemical Analysis of the Idiotypes of Mouse Meyeloma Proteins with Specificity For Levan of Dextran. J. Exp. Med. 139: 137. Smity-Gil, S.J. et. al. 1982. Mapping the antigen epitope for a Monoclonal Antibody Against Lysozyme. J. Immunol. 126: 314. Fu, S.M. et.al. 1975. Similar Idiotype Specificity for the Membrane IgD and IgM of Human B Lymphocytes. J. Immunol. 114: 250. Oettingaer, M.A. et. al. 1990. RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination. Nature, 248:1517. French D.L. et. al. 1989. The Role of Somatic Hypermutation in the Generation of antibody Diversity. Science. 244: 1152. Chen, F.E. et. al 1998. Crystal structure of p50/p65 heterodimer of transcription factor NF-kB bound to DNA. Nature.391: 410. Xian-Feng, Q. et. al. Secondary V(D)J recombination in B-1 cells. Nature: 397, 355. Benacerraf, B. 1981. Role of MHC Gene Products in Immune Regulation. Science, 212: 1229. Margulies D. 1999. The Major Histocompatibility Complex. In Fundamental Immunology edt. W. Paul. Pub. Lippincott-Raven. Brown, J.H. et. al. 1993. Three-dimensional structure of the hman class II histocompatibility antigen HLA-DR1. Nature 364: 33. Davis, M., et.al. 1988. T-cell antigen receptor genes and T-cell recognition. Nature, 334: 395. Nikolic-Zugic, et.al. 1991. Phenotypic and functional stages in the intrathymic developmeant of alpha beta T cells. Immunology Today. 12: 65. Garboczi, D.N., et.al. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134. Bancheraue, J. et.al. 1998. Dendritic cells and the control of immunity. Nature, 392: 245. Springer, T.A. 1990. Adhesion receptaors of the immune system. Nature, 346: 425. Johnson H.M. et.al. Superantigens in Human Disease. Scientific American. April 1992: 92. Goodnow, C. et.al. 1989. Inducation of self-tolerance in mature peripheral B lymphocytes. Nature, 342:385.